A comparison of triazolam and diazepam as premedication agents for minor gynaecological surgery |
| |
| Authors: | C. A. PINNOCK D. FELL P. C. W. HUNT R. MILLER G. SMITH |
| |
| Affiliation: | C.A. Pinnock, MB, BS, FFARCS, Lecturer, D. Fell, MB, ChB, FFARCS, Senior Registrar, P.C.W. Hunt, MB, BS, FFARCS, Senior Registrar, R. Miller, MD, FFARCS, Senior Registrar, G. Smith. BSc, MD, FFARCS. Professor, Department of Anaesthesia, Leicester Royal Infirmary, Leicester LE1 5WW. |
| |
| Abstract: | Triazolam 0.25 mg, diazepam 10 mg and placebo were compared in a randomized double-blind trial of oral premedication in 90 patients undergoing minor gynaecological surgery. Both triazolam and diazepam produced a significant sedative effect as measured by patient self assessment linear analogue scales but only diazepam was more anxiolytic than placebo. Psychomotor performance assessed by the letter-search test at 3 and 6 hours after awakening showed a decrement in performance in patients receiving triazolam at 3 hours compared with the two other groups. Triazolam was shown to have a pronounced amnesic effect and whilst it might be used for premedication, its lack of anxiolysis coupled with a significant impairment of psychomotor performance at 3 hours after awakening, render the drug unsuitable for premedication in the short stay patient. |
| |
| Keywords: | Hyjmotics, benzodiazepines diazepam, triazolam Premedication |
|
|
