Evidence for an involvement of eicosanoids in neurokinin3-receptor mediated acetylcholine release from myenteric neurons. |
| |
| Authors: | W M Yau D J Bowen M L Youther |
| |
| Institution: | Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901-6512. |
| |
| Abstract: | The release of acetylcholine (ACh) from myenteric plexus evoked by 5-hydroxytryptamine (5-HT) and senktide (a selective neurokinin3 (NK3) agonist) was depressed by mepacrine, an inhibitor for phospholipase A2 activity. Release of ACh was stimulated by arachidonic acid; this release was partially depressed by nordihydroguaiaretic acid (NDGA), which inhibits lipoxygenase activity. NDGA failed to modify the ACh secretion elicited by 5-HT. Release of ACh evoked by senktide was significantly inhibited by NDGA, suggesting an involvement of eicosanoids in the release of ACh elicited by specific neurokinin receptors in myenteric neurons. |
| |
| Keywords: | |
|
|
