运动对糖尿病肾病早期相关指标的影响

目的研究运动对糖尿病肾病(DN)早期诊断指标如尿微量白蛋白(Alb)、尿转铁蛋白(TRF)、尿铜蓝蛋白(CP)、尿视黄醇结合蛋白(RBP)的影响。方法对45名2型糖尿病患者做次极量运动试验,运动前后分别测尿Alb、尿TRF、尿CP、尿RBP及尿肌酐(Cr),并以26名非糖尿病人做对照。结果糖尿病患者运动后尿Alb/Cr较运动前增加(P>0.01),尿TRF/Cr,CP/Cr,RBP/Cr运动前后无明显改变;非糖尿病人运动后尿Alb/Cr也较运动前增加(P>0.05),尿TRF/Cr,CP/Cr,RBP/Cr运动前后也无明显改变。而在相关分析中发现,尿RBP/Cr与Alb/Cr无显著相关性。尿TRF/Cr,CP/Cr与Alb/Cr有显著相关性。结论尿Alb/Cr受运动影响而尿TRF/Cr、CP/Cr不受运动影响,可作为DN早期诊断指标之一。

The effect of exercise on early diagnosis indicators of diabetic nephropathy

Objective To study exercise effect on early diagnosis indicators of diabetic nephropathy such as microalbuminuria (Alb),transferrin (TRF),urinary ceruloplasmin (CP) and retinol binding protein (RBP).Methods 45 type 2 diabetic patients have submaximal exercise test.Before exercise and after exercise they are determined Alb,urinary TRF,CP,RBP and creainine (Cr).26 non diabetic people are contrasted.Result Urinary Alb/Cr are added after exercise in diabetic patients,but urinary TRF/Cr,CP/Cr,RBP/Cr are no significant change.Urinary Alb/Cr are added after exercise in non diabetic people,but urinary TRF/Cr,CP/Cr,RBP/Cr are no significant change.Urinary RBP/Cr has no significant relationship with Alb/Cr,but urinary TRF/Cr,CP/Cr have significant relationship with Alb/Cr.Conclusion Urinary Alb/Cr is effected by exercise.Urinary TRF/Cr,CP/Cr,are not effected by exercise,which can be early diagnosis indicators of diabetic nephropathy.