Metabotropic glutamate receptors: phosphorylation and receptor signaling |
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| Authors: | Kim Chul Hoon Lee Jinu Lee Jae-Youn Roche Katherine W |
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| Affiliation: | Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kimhoon@yuhs.ac |
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| Abstract: | Metabotropic glutamate receptors (mGluRs) play important roles in neurotransmission, neuronal development, synaptic plasticity, and neurological disorders. Recent studies have revealed a sophisticated interplay between mGluRs and protein kinases: activation of mGluRs regulates the activity of a number of kinases, and direct phosphorylation of mGluRs affects receptor signaling, trafficking, and desensitization. Here we review the emerging literature on mGluR phosphorylation, signaling, and synaptic function. |
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| Keywords: | mGluR phosphorylation protein kinase protein phosphatase desensitization endocytosis synaptic plasticity |
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