五味子多糖对荷瘤鼠瘤体抑制作用的病理学观察

目的:研究五味子多糖对S180荷瘤鼠的抑瘤作用.方法:采用肿瘤移植的动物模型,对瘤体包埋、制片、HE染色,观察五味子多糖的抑瘤情况.结果:五味子多糖可在一定程度上使瘤细胞退变、凋亡,使瘤内炎细胞增多,瘤周浸润部瘤细胞部分退变,有轻度抑瘤形态学表现.五味子多糖合并环磷酰胺有较强抑瘤作用.结论:五味子多糖具有一定的抑瘤作用,其抑瘤作用可能不是直接杀死瘤细胞,而与细胞凋亡、活化免疫细胞有关.且五味子多糖与环磷酰胺合用可使抑瘤作用增强.

Pathological Observations of Fructus Schisandrae Polysaccharide on Anti-tumor Effects in S180-bearing Mice

Objective:To study the effects of Fructus Schisandrae Polysaccharide(FSP) on anti-tumor in S 180-bearing mice.Methods:The transplantable carcinosarcoma model was established in S 180-bearing mice by subcutaneous implantation.Tumor size and histopathological changes were observed under electron microscopy by HE staining after 8 days treatment.Results:Morphological changes showed that slight cataplasia and apoptosis were induced by high concentration FSP,as well as the numbers of inflammatory cells in tumor were increased and tumor cells in infiltration areas around tumor cataplasised partly.These suggested that high concentration FSP can inhibit tumor growth lightly. In addition, high concentration FSP combined with cyclophosphamide can promote the effect of anti-tumor.Conclusions: FSP can inhibit tumor growth,this effect may be correlated with apoptosis and the activation of immunocytes, but not depend on killing tumor cells directly.In addition, high concentration FSP combined with cyclophosphamide can promote the capacity on anti-tumor in S 180-bearing mice.