| 兔吸入一氧化氮毒副反应的实验研究 |
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| 引用本文： | 江悦华 姜秀英. 兔吸入一氧化氮毒副反应的实验研究[J]. 广东医学, 1998, 19(11): 812-814 |
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| 作者姓名： | 江悦华 姜秀英 |
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| 作者单位： | 广州军区总医院医学实验科!510010 |
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| 基金项目： | 广东省重点科研项目!962204－22 |
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| 摘 要： | 探讨自研一氧化氮吸入装置使受试兔吸入不同浓度ＮＯ的毒副反应。方法：用自研Ｂ－９５１型ＮＯ吸入装置，使受试兔１２周内间断吸入２５、５０、１００ｐｐｍ的ＮＯ，对照组吸正常空气；
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| 关 键 词： | 一氧化氮 吸入 毒副反应 肺动脉高压 哮喘 |
The Side-effects of No Aspiration in Rabbits |
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| Jiang Yuehua, Jiang Xiuying,Liu Zhongming,et al.. The Side-effects of No Aspiration in Rabbits[J]. Guangdong Medical Journal, 1998, 19(11): 812-814 |
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| Authors: | Jiang Yuehua Jiang Xiuying Liu Zhongming et al. |
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| Affiliation: | Jiang Yuehua, Jiang Xiuying,Liu Zhongming, et al. |
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| Abstract: | Objective : The side -effects of various concentrations of NO aspirated thourgh a designed apparatus in rabbits was investigated. Methods: Rabbits were subjected to 25,50, and 100 ppm NO gas treatment during a 12-week period. Those rabbits aspirated atmosphere served as control. An apparatus with microprocessor-interfaced controller was designed and usedfor the aspiration in the investigation. Before and after treatment, ALT, Cr, BUN, MetHb and CBC were monitored. At the end of the investigation , the rabbits were sacrificed and the major organs were histologically examined. Results: There were no significant changes in liver and renal function, CBC, and histological profile of major organs in the rabbits with NO treatment.while a slight increase was observed in MetHb in the rabbits treated with NO at all concentrations used in the study. Conclusion:There were no significant side -effects on the liver, kidneys ,and lungs in the rabbits received logn-term NO aspiration at concentration up to 100 ppm |
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| Keywords: | Rabbit Nitric oxide ihalation Side-effect |
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