大黄、三七粉治疗肾综合征出血热腔道出血的疗效观察

目的研究中药大黄、三七粉对肾综合征出血热腔道出血的治疗作用。方法将临床诊断为肾综合征出血热伴腔道出血患者60例随机分为2组。治疗组31例，予大黄3g、三七2g、研成细末混匀，每日3～4次口服，对照组29例，予止血敏2g，每日1次静脉滴注。结果治疗组痊愈17例，显效5例，有效6例．愈显率为70．97％，总有效率90．32％；对照组痊愈10例，显效3例，有效6例，愈显率为44．83％，总有效率65．52％。两组比较，差异有显著性（P〈0.05，P〈0．01）；治疗组平均止血时间为（2．32±0．82）h，血小板计数为（8．84±1．13）×10^9／L及血小板聚集率明显提高，与对照组[分别为（4．15±0．69）h，（6．22±0．89）×10^9／L]比较，差异均有显著性（P〈0．01）。结论大黄、三七粉有促进血管收缩，缩短出血时间及止血作用，可增加血小板数量，提高血小板聚集功能。

Observation on Therapeutic Effect of Rhubarb and Sanchi Powder in Treating Patients with Hemorrhagic Fever in Nephrotic Syndrome Complicated with Digestive Tract Bleeding

OBJECTIVE: To observe the therapeutic effect of rhubarb and Sanchi Powder (RSP) in treating patients with hemorrhagic fever in nephrotic syndrome (NS) complicated with digestive tract bleeding. METHODS: Sixty patients clinically diagnosed as hemorrhagic fever in NS complicated with digestive tract bleeding were randomized into 2 groups. Fine ground rhubarb (3g) and SP (2g) were given orally to the patients in the treated group 3 - 4 times daily. Dicynonum (2g) was given by intravenously dripping to the patients in the control group. RESULTS: In the treated group, 17 patients were cured, 5 markedly effective and 6 effective, with the markedly effective rate of 70.97% and the total effective rate of 90.32%. The corresponding number in the control group was 10, 3, 6, 44.83% and 65.52%, respectively, significant difference was shown in comparison between the two groups (P < 0.05 or P < 0.01). The average hemostatic time was (2.32 +/- 0.82) h, the platelet count was (8.84 +/- 1.13) x 10(9) /L, and the platelet aggregation rate was obviously improved in the treated group, which were significantly different to those in the control group [(4.15 +/- 0.69) h, (6.22 +/- 0.89) x 10(9)/L, respectively, P<0.01). CONCLUSION: RSP has the action of promoting vasoconstriction, shortening the bleeding time and blood arresting, it can increase the platelet count and improve the platelet aggregation.