纳络酮治疗急性脑梗死临床疗效观察

目的 观察纳络酮治疗急性脑梗死临床疗效。方法 对已确诊的60例急性脑梗死病人随机分为对照组和纳络酮试验组,同时分别给予常规药物治疗和加用纳络酮注射液治疗,治疗前后进行NIH评分和Barthel指数评分,并进行不良反应的观察。结果 试验组30例病人中27例病人临床症状有明显改善,对照组30例病人中20例病人临床症状明显改善,总有效率分别为90％和67％,试验组有效率明显高于对照组,两组有效率之间差异有统计学意义(P<0.05)。未见纳络酮不良反应。结论 纳络酮可能对急性脑梗死患者神经细胞有保护作用,并可促进其神经系统功能恢复,改善预后,减少致残率。

Assessment of clinical effects of naloxone in treating patients with acute cerebral infarction

Objective To assess the effect of naloxone in treating the disease of acute cerebral infarction. Methods Sixty patients of acute cerebral infarction were randomly divided into two groups. One group received routine therapy and the other routine therapy plus naloxone. Neuroprotective effect of naloxone were measured by using NIH stroke scale and Bathel-Index. Adverse effect of the drug was also observed. Results There were 27 patients (90%) improved with clinical manifestations in experiment group, and 20 patients (67%) improved in control group. There is a significant difference between the two groups (P<0.05) . There is no adverse reactions of naxloxone observed. Conclusion Naloxone might protect the nervous cells and restore the function of the nervous system in patients with acute cerebral infraction.