| 麦冬对小鼠镇静催眠作用的初步探讨 |
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| 引用本文： | 赵博,吴长健,高鸿,李兴,张卫国,汪晖.麦冬对小鼠镇静催眠作用的初步探讨[J].咸宁医学院学报,2008,22(4):282-284. |
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| 作者姓名： | 赵博 吴长健 高鸿 李兴 张卫国 汪晖 |
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| 作者单位： | 武汉大学基础医学院药理学系 |
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| 基金项目： | 四川大学CMB华西医学教育研究与发展中心资助项目，湖北省教育厅资助项目 |
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| 摘 要： | 目的观察麦冬对小鼠的镇静催眠作用。方法采用小鼠自主活动记录法、协同阈剂量及阈下剂量戊巴比妥钠镇静催眠法。结果与生理盐水组比较,麦冬大剂量组、艾司唑仑组和复方组均能抑制小鼠的自主活动,并能明显延长小鼠戊巴比妥钠协同阈剂量的睡眠时间,差异有显著性。结论麦冬具有明显的镇静作用。
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| 关 键 词： | 麦冬 镇静 催眠 小鼠 |
Sedative and Hypnotic Effect of Ophiopogon Japonicus on Mice |
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| ZHAO Bo,WU Chang-jian,GAO Hong,et al.Sedative and Hypnotic Effect of Ophiopogon Japonicus on Mice[J].Journal of Xianning Medical College,2008,22(4):282-284. |
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| Authors: | ZHAO Bo WU Chang-jian GAO Hong |
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| Institution: | ZHAO Bo,WU Chang-jian,GAO Hong,et al(Department of Pharmacology;Wuhan University Basic Medical School;Wuhan Hubei 430071;China) |
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| Abstract: | Objective To observe the sedative and hypnotic effects of ophiopogon japonicus in mice.Methods The spontaneous motor activity test and the hypnotic synergism test by threshold and sub-threshold dosage of pentobarbital sodium were employed to evaluate the central pharmacological effect of ophiopogon japonicus.Results Compared with normal saline group,High-dose ophiopogon japonicus could inhibit the spontaneous motor activity and prolong the sleep time of pentobarbital sodium at threshold dosage in mice.There was significant difference between the two groups Conclusion Ophiopogon japonicus has an obvious function of sedation. |
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| Keywords: | Ophiopogon japonicus Sedation Hypnosis Mice |
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