| 吸入麻醉药抑制伤害性逃避反射作用机制的研究进展 |
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| 引用本文： | 杨静,LIU Jin. 吸入麻醉药抑制伤害性逃避反射作用机制的研究进展[J]. 国际麻醉学与复苏杂志, 2008, 29(4) |
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| 作者姓名： | 杨静 LIU Jin |
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| 作者单位： | 四川大学华西医院 |
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| 摘 要： | 遗忘、催眠、制动是全身麻醉的必要组成部分.此文主要总结了以往在3种研究水平(整体动物水平、器官组织水平、细胞分子水平),使用不同的方法(传统药理学的方法,在活体或离体电生理的方法,以及离子通道电化学方法,基因工程技术方法)研究吸入麻醉药作用于脊髓产生制动的机制.
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| 关 键 词： | 制动 伤害性逃避反射 肺泡气最低有效浓度 脊髓 吸入麻醉机制 |
Molecular and systemic mechanisms of inhaled anesthetic inhibiting nociceptive reflex |
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| FANG Jing,LIU Jin. Molecular and systemic mechanisms of inhaled anesthetic inhibiting nociceptive reflex[J]. international journal of anesthesiology and resuscitation, 2008, 29(4) |
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| Authors: | FANG Jing LIU Jin |
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| Abstract: | Amnesia, hypnosis and immobility in response to noxious stimulation are essential components of general anesthesia. This review highlights recent advances in mechanism of inhaled anesthetic-induced immobility by acting on spinal cord at systemic, organic and molecular levels. Inhaled anesthetics cause immobility by modulating multiple molecular targets predominantly in spinal cord including γ-aminobutyric acid A receptors, glycine receptors, glutamate receptors and TREK-1 potassium channels. |
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| Keywords: | immobility nociceptive reflex minimum alveolar concentration spinal cord inhaled anesthetic |
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