老年高血压患者颈动脉硬化与C-反应蛋白、血尿酸和补体的相关性

目的比较老年高血压患者血清C-反应蛋白（CRP）、血尿酸（UA）水平、补体C3与血压及颈动脉硬化程度的相关性。方法将132例老年高血压患者按血压值的不同分为3组，比较各组间CRP、UA与血压的相关性，对各组患者分别检测血生化指标：血清CRP、UA、补体C3，B超观察颈动脉内膜变化，按B超结果将患者分为内膜正常组、内膜增厚组、斑块形成组和管腔狭窄组，各组间CRP、UA、C3水平。结果高血压3级患者CRP、UA显著高于高血压1级、2级患者，差异有统计学意义（P〈0．05）。3组高血压患者CRP、UA值各组间比较差异有统计学意义（P〈0.05）。颈动脉内膜异常组CRP、UA、补体C，值明显高于内膜正常组，差异有统计学意义（P〈0．01）。随着颈动脉内膜-中层厚度（IMT）的增加，UA、CRP的浓度亦逐渐增高；颈动脉内膜异常组各组间比较差异均有显著性（P〈0．05）。结论老年高血压患者颈动脉硬化程度与血压、UA、CRP和补体C3浓度密切相关。老年高血压患者血压、CRP、UA浓度与IMT呈正相关关系（P〈0．01）。

Relationship between the level of C-reactive protein,complement and serum uric acid in elderly patients with carotid atherosderosis and hypertension

Objective To explore the relationship between C-reactive protein （CRP）, C3 and uric acid （UA） in elderly patients with carotid atheroselerosis and hypertension. Methods 132 patients were divided into three groups according to blood pressure, and the change of carotid artery intimae by ultra sound carotid with intimae tricking,plaque shaping and vascular stenosis were observed. The serum concentration of CRP, C3 and UA in each group were measured and compared. Risk factors were analyzed. Results CRP and UA were higher in hypertension 3 grade group than those in 1 and 2 （P 〈0. 01 ）. There was significant differene in the level of CRP and UA in three hypertension groups （ P 〈 0. 05 ）. CRP and UA were higher in carotid artery intimae abnormal group than those in artery intimae normal group （ P 〈 0. 01 ）. CRP and UA were higher,followed by artery intimae tricing （IMT）, UA and CRP in the three hypertension groups （P 〈 0.05 ）. Conclusions Degree of carotid atheroselerosis in the elderly with hypertension were directly correlated with blood pressure and level of UA, C3 and CRP. IMT was positively correlated with blood pressure, CRP and UA.