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| ^125I放射性粒子对乳腺癌细胞内阿霉素浓度影响的实验研究 | |
| 引用本文： | 覃庆洪,韦长元,杨伟萍,李挺,欧超. ^125I放射性粒子对乳腺癌细胞内阿霉素浓度影响的实验研究[J]. 广西医科大学学报, 2009, 26(1) |
| 作者姓名： | 覃庆洪 韦长元 杨伟萍 李挺 欧超 |
| 作者单位： | 1. 广西医科大学 2. 广西医科大学附属肿瘤医院肝胆乳腺科,南宁,530021 3. 广西医科大学附属肿瘤医院超声科 |
| 摘 要： | 目的:采用高效液相色谱法检测乳腺癌细胞中阿霉素(ADM)的含量,探讨125I放射性粒子对乳腺癌细胞内化疗药物ADM浓度的影响.方法:分别采用乳腺癌敏感株MCF-7与耐药株MCF-7/ADM两株乳腺癌细胞,再将其分为MCF-7+ADM组,MCF-7+ADM+125I组, MCF-7/ADM+ADM组,MCF-7/ADM+ADM+125I组共4组,采用HPLC法测定细胞中ADM的含量.结果:在所建立的色谱条件下,测得ADM浓度在0.025～0.5 mg/L范围内呈良好线性关系,相关系数为0.999 9.ADM在各组细胞中的浓度分别为MCF-7+ADM组(0.078±0.005)mg/L,MCF-7+ADM+125I组(0.484±0.016)mg/L, MCF-7/ADM+ADM组(0.458±0.023)mg/L,MCF-7/ADM+ADM+125I组(0.091±0.007)mg/L.结论:联合125I照射能提高化疗药物ADM在乳腺癌敏感株细胞中的浓度,而对耐药株细胞则不能明显提高ADM在细胞内的浓度. |
| 关 键 词： | 乳腺癌 125I放射性粒子 阿霉素 高效液相色谱法 |
EFFECT OF 125I ON THE CONCENTRATION OF DOXORUBICIN (ADM) IN THE BREAST CANCER CELLS |
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| Qin Qinghong,Wei Changyuan,Yang Weiping,et al.. EFFECT OF 125I ON THE CONCENTRATION OF DOXORUBICIN (ADM) IN THE BREAST CANCER CELLS[J]. Journal of Guangxi Medical University, 2009, 26(1) | |
| Authors: | Qin Qinghong Wei Changyuan Yang Weiping et al. |
| Affiliation: | Qin Qinghong,Wei Changyuan,Yang Weiping,et al.(Affiliated Tumor Hospital,Guangxi Medical University,Nanning 530021 China) |
| Abstract: | Objective:To determine the concentration of doxorubicin (ADM) and to investigate the effects of 125I on the concentration of ADM in the breast cancer cells.Methods:Two kinds of the breast cancer cells(sensitive strain MCF-7 and drug-resistant strain MCF-7/ADM)were divided into four groups:MCF-7+ADM,MCF-7+ADM+125I,MCF-7/ADM+ADM,MCF-7/ADM+ADM+125I. High performance liquid chroma-tography(HPLC) was used to determinate the concentration of ADM in the breast cancer cells. Result:A linearity was obtained from 0.0... |
| Keywords: | breast cancer 125I ADM high performance liquid chromatography |
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