Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord |
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Authors: | Yoon Myung Ha Bae Hong Beom Choi Jeong Il Kim Seok Jai Chung Sung Tae Kim Chang Mo |
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Institution: | Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju, Korea. |
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Abstract: | We examined the properties of the drug interaction between morphine and 5-HT(3) receptor antagonist at the spinal level. The nociceptive state was induced by subcutaneously injecting formalin solution (5%, 50 microl) into the hindpaw of the rats. Intrathecal morphine and m-CPBG (5-HT(3) receptor agonist) dose-dependently decreased the flinching response during phase 1 and phase 2 in the formalin test. Intrathecal 5-HT(3) receptor antagonists (LY-278,584 and ondansetron) did not reverse the antinociceptive effect of intrathecal morphine. Intrathecal naloxone had little effect on attenuation of the antinociception of intrathecal m-CPBG. Taken together, no reciprocal interaction was noted between 5-HT(3) receptor and opioid receptors at the spinal level. Thus, the 5-HT(3) receptor antagonist may be useful to manage opioid-induced emesis at the spinal level. |
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