Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N- nitrosourea (MNU) induced mammary tumors in BALB/c mice |
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Authors: | Pazos P; Lanari C; Elizalde P; Montecchia F; Charreau EH; Molinolo AA |
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Institution: | Instituto de Biologia y Medicina Experimental, Academia Nacional de Medicina, Buenos Aires, Argentina. |
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Abstract: | The promoter effect of medroxyprogesterone acetate (MPA) on mammary
carcinogenesis in female BALB/c mice was investigated using
methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed
mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA
(administration of 40 mg every 3 months) starting 1 week after MNU
administration. No tumors appeared in controls receiving only MNU or MPA
during the time course of the experiment (9 months). The tumors were
lobular adenocarcinomas showing different degrees of squamous
differentiation with low or undetectable estrogen and progesterone
receptors, and expressing epidermal growth factor receptors. These results
support the hypothesis that MPA promotes the growth of MNU induced lesions.
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