| 纳米红色元素硒在Beagle犬的药代动力学分析 |
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| 引用本文： | 王学文,郑青山,张劲松,桂常青,胡剑北,孙瑞元.纳米红色元素硒在Beagle犬的药代动力学分析[J].中国临床药理学与治疗学,2004,9(6):673-675. |
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| 作者姓名： | 王学文 郑青山 张劲松 桂常青 胡剑北 孙瑞元 |
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| 作者单位： | 1. 安徽省药物临床评价中心、皖南医学院弋矶山医院,芜湖,241001,安徽
2. 中国科学技术大学经济技术学院,合肥,230027,安徽 |
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| 基金项目： | 安徽省自然科学基金资助课题 (№ 0 10 43 90 3 )，安徽省优秀青年科技基金项目 (№ 0 40 43 0 5 2 ) |
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| 摘 要： | 目的 :观察纳米红色元素硒 (Nse)在Beagle犬的药代动力学特点。方法 :催化荧光法测定用药前基线值和用药后不同时间血硒浓度 ,分别用血硒实测值和上升值计算药动学参数。结果 :Nse代谢符合一室模型 ,吸收较快 ,药峰值为 15 5mg·L-1(实测值 )和 135 .4mg·L-1(上升值 ) ,达峰时间约为 2h ,但消除较慢 ,清除率极低 ,t1 2 长达 34.6h(实测值 )和 2 0h(上升值 )。结论 :长时间、大剂量服用Nse可能导致药物蓄积 ;体内具有基线值时 ,计算药动学参数宜用变化值 ,不宜用实测值
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| 关 键 词： | 纳米红色元素硒 药代动力学 硒 Beagle犬 纳米 |
| 文章编号： | 1009-2501(2004)06-0673-03 |
| 修稿时间： | 2004年5月12日 |
Pharmacokinetic study of the nano red elemental selenium in Beagle dogs |
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| WANG Xue-Wen,ZHENG Qing-Shan,ZHANG Jin-Song ,GUI Chang-Qing,HUO Jian-Bei,SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation & Yijishan Hospital,Wanan Medical College,Wuhu ,Anhui,China, Economic and Technical College,University of Science and Technology of China,Hefei ,Anhui,China.Pharmacokinetic study of the nano red elemental selenium in Beagle dogs[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2004,9(6):673-675. |
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| Authors: | WANG Xue-Wen ZHENG Qing-Shan ZHANG Jin-Song GUI Chang-Qing HUO Jian-Bei SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation & Yijishan Hospital Wanan Medical College Wuhu Anhui China Economic and Technical College University of Science and Technology of China Hefei Anhui China |
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| Institution: | WANG Xue-Wen,ZHENG Qing-Shan,ZHANG Jin-Song 1,GUI Chang-Qing,HUO Jian-Bei,SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation & Yijishan Hospital,Wanan Medical College,Wuhu 241001,Anhui,China, 1 Economic and Technical College,University of Science and Technology of China,Hefei 230000,Anhui,China |
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| Abstract: | AIM: To study the pharmacokinetics of the nano red elemental selenium (Nse) in Beagle dogs. METHODS: Blood levels of selenium were determined before and different times after administration. The observed values and increased values (observed value plus baseline) of blood levels of selenium were used to calculate pharmacokinetic parameters. RESULTS: Nse conformed to one-compartment model with fast absorption and slow elimination. T 1/2 was 34.2 h by observed values in calculation and 20 h by increased values. CONCLUSION: Nse leads to toxicity easily in the administration with long term and large dose. For the material with baseline in body, the pharmacokinetic analysis should use the increased values to calculate parameters. |
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| Keywords: | pharmacokinetics nano red elemental selenium selenium Beagle dogs |
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