子宫颈癌患者循环HPV DNA检测及临床意义的研究进展

近来，癌症患者血浆／血清中肿瘤DNA的临床意义和生物学特忡引起了人们的广泛注意：同样，人们对宫颈癌患者血浆／血清中的人类乳头状瘤病毒（HPV）的DNA亦作了研究。研究采用不同的检测标本（血浆／血清）、不同的DNA抽提方式及不同的引物来检测循环游离HPV DNA，所得的阳性率从6．9％～50％不等。因为宫颈癌患者血浆／血清中的HPV DNA很可能来源于肿瘤本身，这给我们提供了一个新的宫颈癌治疗后的监测工具，特别是针对晚期的患者。可以预测，这一极具有应用前景的分子肿瘤标志物不久将会在临床上被广泛应用。

Research advances in detection and clinical significance of circulating HPV DNA in patients with cervical cancer

Recently,much interest has been focused on the clinical application and biology of tumor-derived DNA in the plasma/serum of cancer patients.Such interest has resulted in the demonstration of human papillomavirus(HPV) DNA in the plasma/serum of patients with cervical cancer(CC).The studies used different materials(plasma /serum),different DNA extraction methods and different primers to detect circulating free HPV DNA,so the positive rates varied from(6.9%) to 50%.The HPV DNA in the plasma/serum of patients suffering from CC most likely originates from the tumor itself,which will probably provide us with a new tool for CC monitoring after primary treatment,especially in patients in advanced stages.It is expected that this promising molecular tumor marker would soon be put into routine clinical use.