Antineopastic natural products and the analogues IV. Aurapten,the cytotoxic coumarin fromPoncirus trifoliata against L1210 cell |
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| Authors: | Kyu Sang Kang Sung Ho Ryu Byung Zun Ahn |
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| Institution: | 1. College of Pharmacy, Chungnam National University, 300-31, Taejeon, Korea
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| Abstract: | A cytotoxic coumarin against L1210 cell was isolated from the unripe fruit ofPoncirus trifoliata (ED50=10.2 μg/ml). Its structure was identified as aurapten, 7-geranyloxycoumarin. Hydrolysis of the substance gave umbelliferone and geraniol. Only geraniol showed the cytotoxic activity (ED50=6.5 μg/ml) while umbelliferone and its methyl or allyl derivatives were not active. |
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