Topical vancomycin formulation for methicillin-resistant Staphylococcus epidermidis blepharoconjunctivitis |
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| Authors: | A B Fleischer D L Hoover J A Khan J T Parisi R P Burns |
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| Affiliation: | 1. Institute of Inorganic Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 36 Bratislava, Slovakia;2. Comenius University, Faculty of Natural Sciences, Department of Inorganic Chemistry, Mlynská dolina, SK-842 15 Bratislava, Slovakia;3. Department of Magnetometry, Institute of Measurement Science, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia;1. Department of Biodiversity, Institute of Biosciences, São Paulo State University, Rio Claro, São Paulo, Brazil;2. Laboratory of Crop Physiology, Department of Plant Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil;3. Laboratory of Plant Physiology “Coaracy M. Franco”, Center R&D of Agricultural Biosystems and Postharvest, Agronomic Institute (IAC), Campinas, São Paulo, Brazil;4. Centre for Research in Biosciences, University of the West of England (UWE), Bristol, United Kingdom |
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| Abstract: | We successfully treated two patients with severe Staphylococcus epidermidis blepharoconjunctivitis by means of a topical vancomycin hydrochloride solution (50 mg/ml) prepared with sterile water. Aqueous vancomycin preparations, however, cause significant ocular irritation probably because of low pH and osmolality values. Solutions prepared with normal saline (5 mg/ml) and phosphate-buffered artificial tears (5 mg/ml and 50 mg/ml) were significantly less irritating and possessed equivalent in vitro antimicrobial activity. Topical vancomycin should be used only when commercially available antibiotics are inadequate. |
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