Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study |
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| Authors: | Mehmet Cindoruk Mustafa Kerem Tarkan Karakan Bulent Salman Okan Akin Murat Alper Ozlem Erdem Selahattin Ünal |
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| Affiliation: | (1) Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey;(2) Department of General Surgery, Gazi University Faculty of Medicine, Ankara, Turkey;(3) Department of Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey;(4) Department of Pathology, Diskapi Training and Research Hospital, Ankara, Turkey;(5) Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey |
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| Abstract: | Background Peroxisome proliferators-activated receptor alpha (PPARα) activation modulates cholesterol metabolism and suppresses bile acid synthesis. This study aims to evaluate the effect of short-term administration of fenofibrate, a PPARα agonist, on proinflammatory cytokines, apoptosis, and hepatocellular damage in cholestasis. |
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