| GRIM-19及其靶基因产物STAT3在胃癌组织中的表达及其意义 |
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| 引用本文： | 张照果,李静,刘岩,李道磊,于世勇,梁晓芳.GRIM-19及其靶基因产物STAT3在胃癌组织中的表达及其意义[J].吉林大学学报(医学版),2011,37(3):499-504. |
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| 作者姓名： | 张照果 李静 刘岩 李道磊 于世勇 梁晓芳 |
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| 作者单位： | 辽宁医学院附属第一医院消化科,辽宁,锦州121000;辽宁医学院附属第一医院消化科,辽宁,锦州121000;辽宁医学院附属第一医院消化科,辽宁,锦州121000;辽宁医学院附属第一医院消化科,辽宁,锦州121000;辽宁医学院附属第一医院消化科,辽宁,锦州121000;辽宁医学院附属第一医院消化科,辽宁,锦州121000 |
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| 基金项目： | 辽宁省科技厅博士启动基金资助课题(20101064) |
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| 摘 要： | 目的:探讨维甲酸-干扰素诱导死亡相关基因-19(GRIM-19)及其靶基因产物STAT3在胃癌组织中的表达及其临床意义,阐明其在胃癌发生和发展过程中的作用.方法:应用 RT- PCR、免疫组织化学染色法和Western blotting法检测48例胃癌组织、癌旁组织及正常胃组织中GRIM-19和STAT3的mRNA及蛋...
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| 关 键 词： | 胃肿瘤 维甲酸-干扰素诱导死亡相关基因-19 转录信号传导子与激活子3 信号转导通路 |
| 收稿时间： | 2010-12-28 |
Expressions of GRIM-19 and its target gene product STAT3 in gastric carcinoma and their significances |
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| ZHANG Zhao-guo,LI Jing,LIU Yan,LI Dao-lei,YU Shi-yong,LIANG Xiao-fang.Expressions of GRIM-19 and its target gene product STAT3 in gastric carcinoma and their significances[J].Journal of Jilin University: Med Ed,2011,37(3):499-504. |
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| Authors: | ZHANG Zhao-guo LI Jing LIU Yan LI Dao-lei YU Shi-yong LIANG Xiao-fang |
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| Institution: | Department of Gastroenterology,First Affiliated Hospital,Liaoning Medical
University,Jinzhou 121000,China |
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| Abstract: | Objective To study the expressions of GRIM-19 and its target gene product STAT3 in human gastric carcinoma(GC)tissues and their clinical significances,and clarify their effects in occurrence and development of gastric carcinoma.Methods RT-PCR,immunohistochemistry dyeing and Western blotting were used to detect the mRNA and protein expressions of GRIM-19 and STAT3 in GC tissues,tissues surrounding carcinoma and normal gastric tisssues.The correlations between the expressions of GRIM-19 and STAT3 and the clin... |
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