| HO/CO在糖尿病肾病大鼠肾脏组织中的表达及其意义 |
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| 引用本文： | 王晓松,成秀梅,曹焕敏,姚晓光,刘斌. HO/CO在糖尿病肾病大鼠肾脏组织中的表达及其意义[J]. 吉林大学学报(医学版), 2011, 37(3): 479-482 |
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| 作者姓名： | 王晓松 成秀梅 曹焕敏 姚晓光 刘斌 |
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| 作者单位： | 河北医科大学中西医结合学院,河北,石家庄,050091;河北医科大学中西医结合学院,河北,石家庄,050091;河北医科大学中西医结合学院,河北,石家庄,050091;河北医科大学中西医结合学院,河北,石家庄,050091;河北医科大学中西医结合学院,河北,石家庄,050091 |
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| 基金项目： | 河北省教育厅科技攻关计划资助课题(2007439) |
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| 摘 要： | 目的:观察糖尿病肾病模型大鼠血浆一氧化碳(CO)的变化和血红素氧合酶-1(HO-1)、血红素氧合酶-2(HO-2)在肾脏组织的表达,探讨血红素氧合酶/一氧化碳(HO/CO)系统在糖尿病肾病发生和发展中的作用.方法:将24只SD大鼠随机分为对照组和模型组,按Anderson等方法建立糖尿病肾病模型.8周后收集尿液测定24...
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| 关 键 词： | 糖尿病肾病 大鼠 内源性一氧化碳 血红素氧合酶-1 血红素氧合酶-2 |
| 收稿时间： | 2010-11-23 |
Expression of HO/CO in kidney tissue of diabetic rats and its significance |
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| WANG Xiao-song,CHENG Xiu-mei,CAO Huan-min,YAO Xiao-guang,LIU Bin. Expression of HO/CO in kidney tissue of diabetic rats and its significance[J]. Journal of Jilin University: Med Ed, 2011, 37(3): 479-482 |
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| Authors: | WANG Xiao-song CHENG Xiu-mei CAO Huan-min YAO Xiao-guang LIU Bin |
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| Affiliation: | College of Integrated Traditional and Western Medicine,Hebei Medical University Shijiazhuang |050091|China |
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| Abstract: | Objective To observe the change of plasma carbon monoxide(CO) and the expressions of heme oxygenase-1(HO-1) and heme oxygenase-2(HO-2) in kidney tissues,and explore the effect of heme oxygenase/carbon monoxide(HO/CO)on development and progression of diabetic nephropathy.Methods 24 Sprague-Dawley rats were randomly divided into control group and model group,The rat models with diabetic nephropathy were established according to Anderson' method.8 weeks later,the urine of rats were collected to measure the 24 ... |
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| Keywords: | diabetic nephropathy rat carbon monoxide heme oxygenase-1 heme oxygenase-2 |
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