| 东北林蛙皮肤抗菌肽dybowskin-1ST 对小鼠皮肤创伤愈合的作用 |
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| 引用本文： | 苗慧敏,肖向红,孙婷婷,漆俊,柴龙会,张晶钰,郭娜.东北林蛙皮肤抗菌肽dybowskin-1ST 对小鼠皮肤创伤愈合的作用[J].中国实验方剂学杂志,2011,17(23):125-128. |
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| 作者姓名： | 苗慧敏 肖向红 孙婷婷 漆俊 柴龙会 张晶钰 郭娜 |
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| 作者单位： | 东北林业大学野生动物资源学院,哈尔滨,150040 |
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| 基金项目： | 国家自然科学基金项目(30870303);黑龙江省自然科学基金重点项目(ZJN0604-02);东北林业大学研究生科技创新项目 |
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| 摘 要： | 目的:研究东北林蛙(Rana dybowskii Günther,1876)皮肤抗菌肽(dybowskin-1ST)对小鼠皮肤损伤模型创伤愈合的影响。方法:将60只健康成年小鼠随机分为甘油对照组、外用应急软膏组和dybowskin-1ST组(50 mg.L-1,10μg/只),制备皮肤损伤模型,将供试品按0.2 mL/只的剂量涂抹创口外延至2～3 mm,1次/d。于损伤后第1,3,5,7天测量皮肤损伤面积,计算伤口愈合率,第3,7天取损伤部位皮肤,组织切片观察其形态学变化。结果:第7天dybowskin-1ST组和外用应急软膏组小鼠皮肤损伤部位愈合率分别为(86.74±0.27)%和(91.57±0.14)%,与甘油对照组比较,提高了16.04%和20.87%,P<0.05;组织形态学显示,dybowskin-1ST组愈合初期新生组织的毛细血管和成纤维细胞数量增多,愈合后期组织分层明显,且与外用应急软膏组无明显差异。结论:dybowskin-1ST能改善小鼠损伤部位肉芽组织生长状态和胶原纤维形成,促进伤口愈合。
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| 关 键 词： | 皮肤抗菌肽 东北林蛙 创伤愈合 |
| 收稿时间： | 2011/5/16 0:00:00 |
Study on Effect of Antimicrobial Peptides Dybowskin-1ST from Skin of Rana dybowskii on Wound Healing Skin of Mice |
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| MIAO Hui-min,XIAO Xiang-hong,SUN Ting-ting,QI Jun,CHAI Long-hui,ZHANG Jing-yu and GUO Na.Study on Effect of Antimicrobial Peptides Dybowskin-1ST from Skin of Rana dybowskii on Wound Healing Skin of Mice[J].China Journal of Experimental Traditional Medical Formulae,2011,17(23):125-128. |
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| Authors: | MIAO Hui-min XIAO Xiang-hong SUN Ting-ting QI Jun CHAI Long-hui ZHANG Jing-yu and GUO Na |
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| Institution: | College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China;College of Wildlife Resources, Northeast Forestry University, Harbin 150040, China |
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| Abstract: | |
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| Keywords: | dybowskin-1ST Rana dybowskii wound healing mice |
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