理气润肠方治疗阿片类药物相关性便秘的疗效观察

目的观察理气润肠方治疗阿片类药物相关性便秘的临床效果。方法选取2017年7月—2019年1月因阿片类药物导致的气虚气滞型便秘患者104例,将其按照随机数字表法分为对照组、观察组各52例。对照组给予乳果糖口服溶液治疗,观察组口服中药理气润肠方治疗,2组均连续治疗2周。对比2组治疗前后便秘症状评分、中医证候积分,对比2组疗效,评价2组安全性。结果治疗前2组便秘症状评分比较差异无统计学意义(P>0.05);治疗后2组症状评分均较治疗前降低(P<0.05),且治疗后观察组症状评分低于对照组(P<0.05)。治疗后2组中医证候积分均较治疗前降低(P<0.05),且治疗后观察组中医证候积分低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。2组治疗后血尿便常规、肝肾功能、心电图均无明显变化。对照组5例患者出现腹胀、恶心,考虑为乳果糖口服溶液不良反应,未予处理,后均自行缓解。观察组未发生不良反应。结论理气润肠方能有效缓解阿片类药物相关性便秘患者的症状,效果优于乳果糖口服溶液。

Clinical observation of Liqi Runchang Recipe on opioid-induced constipation

Objective To observe the effects of Liqi Runchang Recipe on opioid-induced constipation.Methods 104 patients with constipation of Qi deficiency and Qi stagnation caused by using opioids were randomly divided into control group and treatment group with random number table method.The control group(n=52)was given oral Lactulose Oral Solution.The treatment group was given orally Liqi Runchang Recipe.Both two groups were treated for 2 weeks as a course of treatment.The score,TCM syndrome score before and after the treatment and the therapeutic effects of between the two groups were compared and the safety evaluated.Results There was no statistical difference between two groups before the treatment(P>0.05);the symptom score of two groups after the treatment were lowered(P<0.05),and the symptom score of treatment group was more lowered than that of the control group(P<0.05).The scores of TCM syndromes in both groups were decreased after treatment(P<0.05),and the scores in the treatment group were more significantly lowered than those in the control group(P<0.05).After the treatment,the findings of blood and stool routine,liver and kidney function,and ECG in both groups had no obvious changes.5 cases in the control group showed abdominal distension and nausea,which are probably the adverse reactions of Lactulose Oral Solution,so without management,these symptoms were alleviated.Any adverse reactions were found in the treatment group.Conclusion Liqi Runchang Recipe can effectively alleviate opioidinduced constipation,which has better effect than Lactulose Oral Solution.