| 蛇毒抗栓酶对心血管系统影响的初步研究 |
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| 引用本文： | 常天辉,李伯坚,姚宏,张克义,郝文学. 蛇毒抗栓酶对心血管系统影响的初步研究[J]. 中国医科大学学报, 1985, 0(5) |
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| 作者姓名： | 常天辉 李伯坚 姚宏 张克义 郝文学 |
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| 作者单位： | 中国医科大学药理学教研室，中国医科大学药理学教研室，本溪市卫校，中国医科大学，中国医科大学蛇毒研究组 进修教师 |
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| 摘 要： | 本文通过颈动脉插管法,ECG技术及离体心脏灌流实验,初步证明:蛇毒抗栓酶(Svate)具有降低动脉血压,增加心输出量,抑制心肌收缩力及减少冠流量等作用。在一定剂量下,对心率无明显影响。
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| 关 键 词： | 蛇毒抗栓酶 兔 颈动脉血压 心灌流 |
THE PRELIMINARY STUDIES OF SNAKE VENOM ANTITHROMBUS ENZYME (Svate) ON CARDIOVASCULAR SYSTEM |
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| Chang Tianhui,et al. THE PRELIMINARY STUDIES OF SNAKE VENOM ANTITHROMBUS ENZYME (Svate) ON CARDIOVASCULAR SYSTEM[J]. Journal of China Medical University, 1985, 0(5) |
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| Authors: | Chang Tianhui et al |
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| Affiliation: | Chang Tianhui,et al Department of Pharmacology |
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| Abstract: | Using the methods of cannulation of the carotid artery and ECG inurethane-anesthetized rabbits and perfusion in Yaki-Hartung's heart of toad and Langendorff's heart of rabbit, our preliminary expriments have provedthat Svate has a significant hypotensive effect and an inhibition of cardiaccontractility. In addition, it also can increase the cardiac output and decreasethe volume rate of ceronary blocd cutflow. Within the limits of dosage therewas no marked influence on heart rate. |
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| Keywords: | Snake venom antithrombus enzyme(Svate) Rabbit blood pressure of carotid artery Perfusion in Yaki's heart |
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