脑血管病患者胃动素的临床研究

目的：观察脑出血（ＣＨ）、脑梗死（ＣＩ）、蛛网膜下腔出血（ＳＡＨ）患者胃动素（ＭＴＬ）水平的动态变化及其临床意义。方法：选择脑血管病（ＣＶＤ）患者１３８例。用放免法检测血浆ＭＴＬ浓度。结果：ＣＶＤ各组ＭＴＬ水平显著高于对照组，发病２４ｈ内即升高；ＣＩ组、ＳＡＨ组４～７ｄ达峰水平，ＣＨ组１～３ｄ达峰水平，８～１５ｄ降低，１５ｄ仍在较高水平；随病情严重程度的加重ＭＴＬ水平升高；高血糖组显著高于正常血糖

A clinical study on levels of motilin in plasma in patients with cerebrovascular disease

Objective:To observe levels of motilin in plasma and its clinical significance in patients with cerebral hemorrhage or cerebral infarction or subarachnoid hemorrhage.Methods: The levels of motilin in plasma were measured by radioimmunoassay in 138 cases of cerebrovascular disease and 28 healthy control subjects. Results: The levels of motilin in plasma in the three groups of cerebrovascular disease were increased more than that in control group. The levels of motilin in plasma in the three groups started to increase significantly during the first day. The levels of motilin in plasma reached the peak in the three groups of cerebrovascular disease on day 1 to 3 or day 4 to 7. They began to decrease from the eighth day. The levels of motilin in the three groups of cerebrovascular disease were higher than that in control group after 15 days. The severer the condition of cerebrovascular diseases , the higher the motilin levels. Conclusion: Motilin plays a major role in pathophysiological and pathogenetic mechanisms of cerebrovascular disease .