首页 | 本学科首页   官方微博 | 高级检索  
     

乙肝病毒表面抗原阳性孕妇产前病毒感染状态分析
引用本文:翟祥军,刘耀珍,刘红建,刘黎静,张秋民,纪学中,周余春,曹名权,孙翔,朱叶飞,朱立国,卞倩,彭红,许卫国,鲍倡俊,羊海涛,李杰,朱凤才,庄辉. 乙肝病毒表面抗原阳性孕妇产前病毒感染状态分析[J]. 江苏预防医学, 2012, 23(6): 17-19
作者姓名:翟祥军  刘耀珍  刘红建  刘黎静  张秋民  纪学中  周余春  曹名权  孙翔  朱叶飞  朱立国  卞倩  彭红  许卫国  鲍倡俊  羊海涛  李杰  朱凤才  庄辉
作者单位:翟祥军 (江苏省疾病预防控制中心,南京,210009);刘耀珍 (江苏省淮安市淮安区疾病预防控制中心,淮安,223200); 刘红建 (江苏省泰兴市疾病预防控制中心,泰州,225400);刘黎静 (江苏省泰兴市疾病预防控制中心,泰州,225400);张秋民 (江苏省淮安市淮安区疾病预防控制中心,淮安,223200);纪学中 (江苏省淮安市淮安区疾病预防控制中心,淮安,223200); 周余春 (江苏省泰兴市疾病预防控制中心,泰州,225400);曹名权 (江苏省泰兴市疾病预防控制中心,泰州,225400);孙翔 (江苏省疾病预防控制中心,南京,210009); 朱叶飞 (江苏省疾病预防控制中心,南京,210009); 朱立国 (江苏省疾病预防控制中心,南京,210009); 卞倩 (江苏省疾病预防控制中心,南京,210009);彭红 (江苏省疾病预防控制中心,南京,210009); 许卫国 (江苏省疾病预防控制中心,南京,210009); 鲍倡俊 (江苏省疾病预防控制中心,南京,210009); 羊海涛 (江苏省疾病预防控制中心,南京,210009); 李杰(北京大学医学部,北京,100191); 朱凤才(江苏省疾病预防控制中心,南京,210009); 庄辉(北京大学医学部,北京,100191);
基金项目:传染病科技重大专项(2012ZX10002-001,2011ZX10004-902)
摘    要:目的了解乙肝病毒表面抗原(HBsAg)阳性孕妇中乙肝病毒(HBV)感染相关指标分布特征,以评价HBV母婴阻断失败高危因素的分布强度及影响因素。方法采用现况调查方法,对2009年8月-2010年12月期间入选的895名HBsAg阳性孕妇进行人口学信息、与HBV感染相关的信息调查,采集血液样品检测HBsAg、HBeAg、抗-HBe及HBV DNA滴度等指标,并对结果进行统计分析。结果 HBsAg阳性孕妇产前HBeAg阳性率为33.4%,HBV DNA载量>107IU/ml者占25.2%,HBsAg滴度≥10 000IU/mL者占29.61%;HBeAg阳性者中,HBsAg滴度与HBV DNA载量间存在密切正相关关系(r=0.53,P<0.01);随孕妇年龄的增加,孕妇产前HBeAg阳性率和HBV DNA载量均有明显降低趋势。结论 HB-sAg阳性孕妇中存在母婴阻断失败高危险因素的比例较高。适当推迟怀孕年龄,可降低HBsAg阳性人群HBV母婴阻断失败的风险。

关 键 词:乙型肝炎病毒  孕妇  母婴阻断  危险因素  阳性率

Analysis of the HBV infection status in HBsAg positive pregnant women prior to their delivery
ZHAI Xiang-jun,LIU Yao-zhen,LIU Hong-jian,LIU Li-jing,ZHANG Qiu-ming,JI Xue-zhong,ZHOU Yu-chun,CAO Ming-quan,SUN Xiang,ZHU Ye-fei,ZHU Li-guo,BIAN Qian,PENG Hong,XU Wei-guo,BAO Chang-jun,YANG Hai-tao,LI Jie,ZHU Feng-cai,ZHUANG Hui. Analysis of the HBV infection status in HBsAg positive pregnant women prior to their delivery[J]. Jiangsu Journal of Preventive Medicine, 2012, 23(6): 17-19
Authors:ZHAI Xiang-jun  LIU Yao-zhen  LIU Hong-jian  LIU Li-jing  ZHANG Qiu-ming  JI Xue-zhong  ZHOU Yu-chun  CAO Ming-quan  SUN Xiang  ZHU Ye-fei  ZHU Li-guo  BIAN Qian  PENG Hong  XU Wei-guo  BAO Chang-jun  YANG Hai-tao  LI Jie  ZHU Feng-cai  ZHUANG Hui
Affiliation:Jiansu Provincia
Abstract:Objective To explore the distribution of HBV infection biomarkers in HBsAg positive pregnant women, and an alyze the causes of this distribution. Methods From Aug. 2009 to Nov. 2010, a structured questionnaire on demographic data was administered to eight hundred and ninety five HBsAg positive pregnant women, from whom blood samples were then col lected to test for HBsAg, HBeAg, Anti HBe and HBV DNA. The collected data were analyzed by SPSS software. ResultsOf the 895 subjects, 33.4% were HBeAgpositive, and 25.2% had HBV DNA levels of 107 IU/mL. Among HBeAg positive pregnant women, HBsAg titers were positively correlated with HBV DNA level (r= 0. 53,P〈0. 01). There was a trend of decreased risk of mothertoinfant transmission with the increasing age. Conclusion In Chinese HBsAgpositive pregnant women, risk of HBV mothertoinfant transmission is relatively high, and delaying the age of pregnancy may low er the risk of HBV mothertoinfant transmission.
Keywords:HBsAg pregnant women block mother- to- infant transmission risk Sactor positive rate
本文献已被 CNKI 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号