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New method for bioavailability assessment of slow-release preparations of theophylline |
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| Authors: | Yasuji Kasuya Tetsuro Ohno Noriyoshi Kubota Hidenori Takahashi Hiroki Hirayama |
| Institution: | (1) Department of Clinical Pharmacy, Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, 192-03 Tokyo, Japan;(2) Present address: Department of Pharmacy, St. Marianna University Hospital, 2095 Sugoh, Miyamae-ku, Kawasaki, 213 Kanagawa, Japan |
| Abstract: | Variability in an individual's clearance of theophylline is an important consideration when estimating bioavailability. A method is described for compensating for this problem, using the serum concentration of theophylline and urinary excretion data on its major metabolites to make an estimation of the clearance after oral administration using the intravenous dose as reference. The method is particularly useful for assessing the bioavailability of slow-release theophylline preparations. |
| Keywords: | theophylline bioavailability variability in clearance siow-release preparations urinary metabolites |
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