| 超临界状态下压力对穿心莲内酯萃取结晶的影响 |
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| 引用本文： | 张文成,潘见,陈克勋,谢慧明. 超临界状态下压力对穿心莲内酯萃取结晶的影响[J]. 中草药, 2004, 35(3): 262-264 |
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| 作者姓名： | 张文成 潘见 陈克勋 谢慧明 |
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| 作者单位： | 1. 合肥工业大学,农产品生物化工教育部重点实验室,安徽合肥,230069
2. 中国科学技术大学化学与材料学院,安徽合肥,230026 |
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| 基金项目： | 国家自然科学基金资助项目 (2 99760 0 8) |
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| 摘 要： | 目的 利用超临界CO2萃取结晶技术纯化穿心莲内酯。方法 采用系统观察法考察了超临界CO2萃取结晶分离对穿心莲内酯晶体形态、纯度、结晶量的影响，并采用扫描电镜、HPLC法分析结果。结果 穿心莲内酯晶体形态随压力的升高而变细、变短；随着压力的升高，晶体纯度提高，结晶量增加。结论 超临界CO2能萃取并同步高效结晶分离穿心莲内酯，为开发高质量中药活性成分提供一条捷径。
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| 关 键 词： | 穿心莲内酯 超临界CO2 流体萃取 结晶 |
| 文章编号： | 0253-2670(2004)03-0262-03 |
| 收稿时间： | 2003-05-30 |
Effect of pressure in supercritical state on extraction and crystallization of andrographolide |
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| ZHANG Wen-cheng,PAN Jian,CHEN Ke-xun and XIE Hui-ming. Effect of pressure in supercritical state on extraction and crystallization of andrographolide[J]. Chinese Traditional and Herbal Drugs, 2004, 35(3): 262-264 |
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| Authors: | ZHANG Wen-cheng PAN Jian CHEN Ke-xun XIE Hui-ming |
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| Affiliation: | ZHANG Wen-cheng1,PAN Jian1,CHEN Ke-xun2,XIE Hui-ming1 |
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| Abstract: | Object To separate and purify andrographolide by supercritical CO 2 extraction and crystallization. Methods The method of systematic observation was used to investigate the crystal appearance, purity and mass of andrographolide by supercritical CO 2 extraction and crystallization, analyzing by scanning electron microscope (SEM) and HPLC. Results The higher the pressure, the smaller and shorter the crystal shape, and the purer the purity, the more the mass of andrographolide. Conclusion This technique is a innovation of traditional supercritical fluid extraction (SCFE) technique, which realizes highly effectual separation of andrographolide by supercritical CO 2 extraction and synchronous crystallization, developes a new technology to separate andrographolide and other active ingredients from Chinese traditional herbs. |
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| Keywords: | andrographolide supercritical CO 2 fluid extraction crystallization |
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