| RELATIONSHIP BETWEEN THE MUTATION OF P53 GENE AND INFILTRATION，METASTASIS AND PROGNOSIS OF GASTRIC CARCINOMA |
| |
| 引用本文： | 辛彦,赵凤凯,吴东瑛,王艳萍,徐蕾,张荫昌.RELATIONSHIP BETWEEN THE MUTATION OF P53 GENE AND INFILTRATION，METASTASIS AND PROGNOSIS OF GASTRIC CARCINOMA[J].中国癌症研究,1996,8(4):263-266. |
| |
| 作者姓名： | 辛彦 赵凤凯 吴东瑛 王艳萍 徐蕾 张荫昌 |
| |
| 摘 要： | ＲＥＬＡＴＩＯＮＳＨＩＰＢＥＴＷＥＥＮＴＨＥＭＵＴＡＴＩＯＮＯＦＰ５３ＧＥＮＥＡＮＤＩＮＦＩＬＴＲＡＴＩＯＮ，ＭＥＴＡＳＴＡＳＩＳＡＮＤＰＲＯＧＮＯＳＩＳＯＦＧＡＳＴＲＩＣＣＡＲＣＩＮＯＭＡＸｉｎＹａｎ辛彦；ＺｈａｏＦｅｎｇｋａｉ赵凤凯；ＷｕＤｏｎｇ...
|
Relationship between the mutation of P53 gene and infiltration,metastasis and prognosis of gastric carcinoma |
| |
| Yan Xin,Fengkai Zhao,Dongying Wu,Yanping Wang,Lei Xu,Yinchang Zhang,Kristin Henry.Relationship between the mutation of P53 gene and infiltration,metastasis and prognosis of gastric carcinoma[J].Chinese Journal of Cancer Research,1996,8(4):263-266. |
| |
| Authors: | Yan Xin Fengkai Zhao Dongying Wu Yanping Wang Lei Xu Yinchang Zhang Kristin Henry |
| |
| Institution: | 1. Cancer Institute, China Medical University, 110001, Shenyang
2. Department of Histopathology, Charring Cross & Westminster Medical School, University of London, UK
|
| |
| Abstract: | gastric carcinomas were examined immunohistochemically with McAb to p53 protein in order to investigate the relationship between the expression of p53 protein and histological differentiation of gastric carcinoma, and to approach the mechanism of infiltration and metastasis of gastric carcinoma. The results showed that nuclear expression of p53 protein was significantly related to tumor size, depth of invasion, lymph node and liver metastases; but not related to histological differentiation. It is suggested that the accumulation of p53 protein was increased with the progression of gastric carcinoma, and therefore the cancer clone with p53 gene mutation may play an important role in the development of tumor invasion and metastasis. |
| |
| Keywords: | p53 gene Tumor suppresser gene Metastasis Gastric carcinoma |
| 本文献已被 SpringerLink 等数据库收录！ |
|
