介入栓塞术后疼痛的预防性治疗的临床研究

目的:评价芬太尼透皮贴剂结合糖皮质激素类药物预防性治疗介入栓塞术后疼痛的疗效、安全性及对生活质量的影响。方法:133例需行介入栓塞术的患者随机分为2组,治疗组69例于术前12h使用多瑞吉(Durogesic,芬太尼透皮贴剂),栓塞前30min预防使用地塞米松10~20mg肌肉注射,术后继续给予地塞米松10~20mg肌肉注射,连续3d;对照组64例术后疼痛时给予曲马多200mg口服。术后3d评价2组患者疼痛、安全性及对生活质量的影响。结果:治疗组预防性止痛效果显著(P<0.05),不良反应轻,可有效地改善患者的生活质量。结论:芬太尼透皮贴剂结合地塞米松可有效地预防栓塞治疗后疼痛的发生。

Clinical Studies of pain after Treatmeut of Intervention Embolization

Objective:To estimate anti-pain effect of Durogesic combined with dexamethasone after interventional embolism therapy. Methods:133 patients who needed embolism therapy were divided into two groups randomly. 69 Patients in treated group used Durogesic 12 hours before operation, and received dexamethasone 10~20mg I.m thirty minutes before operation, which continued for 3 days. 64 patients in contrast group received Tramadol 200mg by mouth when they felt pain after operation. The effects of two treatments in anti-pain, safety, and quality of life were evaluated. Results:Therapy in treated group was better than that in contrast group(P <0.05). The adverse effects was light in treated group, which could improve the quality of life of the patients. Conclusion:Durogesic combined with dexamethasone can be used as a good anti -pain method after interventional embolism therapy.