Prevalence and genetic relatedness of community-acquired methicillin-resistant Staphylococcus aureus in Israel |
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| Authors: | G. Regev-Yochay Y. Carmeli M. Raz E. Pinco J. Etienne A. Leavitt E. Rubinstein S. Navon-Venezia |
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| Affiliation: | (1) Infectious Diseases Unit, Sheba Medical Center, Ramat-Gan, Israel;(2) Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel;(3) Division of Epidemiology and Laboratory for Molecular Epidemiology and Antimicrobial Research, Tel Aviv Medical Center, Tel-Aviv, Israel;(4) Maccabi Healthcare Services, Rishon-Lezion, Israel;(5) Faculte de Medecine Laennec, INSERM E0230, Lyon, France;(6) Present address: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA |
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| Abstract: | The aims of the study presented here were to determine the prevalence of Staphylococcus aureus carriage and, specifically, community-acquired methicillin-resistant S. aureus (CA-MRSA) carriage in children and their parents in Israel and to determine the genetic relatedness of these isolates. S. aureus was isolated from 580 of 3,373 (17.2%) individuals screened. The predominant type identified by pulsed-field gel electrophoresis was strain ST45-MSSA (25%). Five MRSA isolates were detected, and two of these were classified as CA-MRSA, based on the following criteria: no previous contact with a healthcare facility, absence of a multidrug-resistant (MDR) phenotype, and presence of SCCmec type IV. Isolates were negative for pvl and were classified as ST-45-MRSA. Although CA-MRSA is still rare in Israel, the genetic relatedness of the strains found in this study to a successful MSSA clone warrants close follow up.This study was presented in part at the 43rd ICAAC meeting, Chicago, IL, USA, September 2003 (Abstact no. 1975). |
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