氯吡格雷对支气管哮喘患者P-选择素影响的研究

目的 观察支气管哮喘患者血清P-选择素的变化,探讨氯吡格雷治疗哮喘的疗效.方法 将60例支气管哮喘患者随机分为两组,常规治疗组和氯吡格雷组（氯吡格雷＋常规治疗）,选择健康体检者为对照组（30名）,进行观察.测定哮喘患者急性发作期和缓解期血清P-选择素水平的变化,同步检测肺功能第一秒用力呼气量（FEV1）、最大呼气流速（PEF）.结果 （1）哮喘患者急性发作期血清P-选择素水平较对照组明显升高（P均＜0.01）.氯吡格雷组缓解期血清P-选择素水平较常规治疗组缓解期明显下降（P均＜0.01）.哮喘患者血清P-选择素水平与FEV1、PEF比较成负相关;（2）氯吡格雷组患者缓解时间少于常规治疗组（P＜0.01）;（3）氯吡格雷组患者人均静脉用甲基强的松龙用量明显少于常规治疗组（P＜0.05）.结论 支气管哮喘患者急性发作期、缓解期血清P-选择素水平较对照组升高,氯吡格雷可以降低血清P-选择素水平,可作为辅助治疗支气管哮喘的药物之一.

Study on the effect of Clopidogrel to P-selectin in asthma patients

Objective To observe the effect of serum P-selectin in acute asthma,and to explore the possible therapeutic of Clopidogrel on asthma.Methods 60 asthma patients were randomly divided into two groups,the routine treatment group,using Clopidogrel and the routine treatment group,and 30 normal controls.The serum P-selectin were measured in the two groups with acute asthma compared with the controls.PEF,FEV1 were measured at the same time.Results (1)The level of serum P-selectin were all significantly increased in the two groups with the acute asthma as compared with the normal individuals group(P<0.01).The level of serum P-selectin were all significantly decreased in patients using Clopidogrel as compared with the routine treatment,and the pulmonary function improved(P<0.01).The level of serum P-selectin in patients with asthma were negatively correlated with PEF,FEV1.(2) The alleviation time of asthma were all significantly decreased in patients using Clopidogrel and the routine treatment as compared with the routine treatment(P<0.01).(3)The dosage of glucocorticoid intravenously were all significantly decreased in patients using Clopidogrel and the routine treatment as compared with the routine treatmen(P<0.05).Conclusion The serum P-selectin were all significantly increased in patients with asthma group as compared with the normal group,Clopidogrel can decrease the level of serum P-selectin,can be a assistance medicine in treating asthma.