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| ATP-MgCl_2对烫伤大鼠肠粘膜保护作用的实验观察 | |
| 引用本文： | 苏映军,陈璧,汤朝武,贾赤宇. ATP-MgCl_2对烫伤大鼠肠粘膜保护作用的实验观察[J]. 中华烧伤杂志, 1996, 0(3) |
| 作者姓名： | 苏映军 陈璧 汤朝武 贾赤宇 |
| 作者单位： | 第四军医大学西京医院烧伤科，第四军医大学西京医院烧伤科，第四军医大学西京医院烧伤科，第四军医大学西京医院烧伤科 |
| 摘 要： | 为研究 ATP-MgCl_2对创伤应激动物肠粘膜的保护作用,采用30%TBSAⅢ度烫伤大鼠模型,观察了腹腔注射 ATP-MgCl_2复合液对回肠粘膜丙二醛(MDA)含量及回肠组织形态学改变的影响。结果显示:烫伤后6～24小时,MDA 含量明显升高,并伴有形态学病理改变。经 ATP-MgCl_2注射治疗的大鼠伤后24小时内 MDA 含量维持于正常对照水平,且回肠粘膜病理改变减轻。提示:ATP-MgCl_2能够保护烫伤大鼠肠粘膜,其作用机理可能与降低肠粘膜的脂质过氧化反应有关。 |
| 关 键 词： | ATP-MgCl_2 烧伤 丙二醛 脂质过氧化 |
Protective effect of ATP-MgCl_2 on gut mucosa in burn rat. |
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| Su Yingjun Chen Bi Tang Chaowu. Protective effect of ATP-MgCl_2 on gut mucosa in burn rat.[J]. Chinese journal of burns, 1996, 0(3) | |
| Authors: | Su Yingjun Chen Bi Tang Chaowu |
| Affiliation: | Su Yingjun Chen Bi Tang Chaowu Department of Burn Surgery,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032 |
| Abstract: | In order to study the protective effect of ATP-MgCl_2 on gut mucosal barrier function in trauma-induced stressed animal,full thickness burn of 30% total body surface area (TBSA) was pro- duced in rats,and ATP-MgCl_2 was injected intraperitoneally right after scald-injury.Malondialdehyde (MDA) contents of ileum mucosa were determined and morphological alteration in the ileum was ob- served under light microscope.The results showed that ileum mucosal MDA content increased signifi- cantly,accompanied by obvious morphological change,after the injury,whereas MDA content was main- tained at the normal control level and pathological alteration in ileum tissue was abated after the use of ATP-MgCl_2.It suggests that ATP-MgCl_2 possesses a protective effect on gut mucosal barrier function of scald-injured rat,and the mechanism involved may be related to the inhibition of lipid peroxidation in gut mucosa. |
| Keywords: | ATP-MgCl_2 Burn Malondialdehyde Lipid peroxidation |
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