Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp |
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Authors: | Andersen Yolanda S Gillin Frances D Eckmann Lars |
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Institution: | Department of Medicine 0665, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0665, USA. |
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Abstract: | Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance. |
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