胃液糖类抗原19-9/72-4联合检测对胃癌的诊断价值

目的 探讨胃液糖类抗原72-4(CA72-4)、糖类抗原19-9(CA19-9)联合检测诊断胃癌的可行性.方法 应用自制胃液采集器通过胃镜分别采集研究组胃癌30例、对照组萎缩性胃炎32例、胃溃疡30例 和慢性浅表性胃炎30例患者的胃液,以ES-300全自动酶免分析仪批量同步检测CA72-4、CA19-9的表达.结果 研究组CA72-4、CA19-9检测水平分别为(83.54±143.70)U/ml和(47.05±29.64)U/ml,阳性检出率分别为76.66%和43.33%,均明显高于对照组(P<0.01);两者联合检查阳性率可达80.00%,32例萎缩性胃炎有2例CA72-4升高,其中1例患者9个月后确诊为胃癌.结论 胃液CA72-4、CA19-9联合检测可作为胃癌诊断的参考依据,也是晚期胃癌的重要指标.

Clinical value of combined detection of CA72-4,CA19-9 in gastric juice in diagnosis of gastric carcinoma

Objective To explore the possibility of united test of CA72-4, CA19-9 in gastric juice in diagnosis of gastric carcinoma.Methods The gastric juices were respectively obtained by liquid collector made by ourselves through gastreecope in study group(30 cases of gastric cancer) and control groups(32 cases of gastratrophia,30 cases of gastric ulcer,and 30 cases of chronic superficial gastritis).The gastric juice content of CA72-4, CA19-9 were determined synchronously with ES-300 auto-enzymoimmuno-analyzer.Results The gastric juice contents of CA72-4,CA19-9 were (83.54±143.70) U/ml and (47.05±29.64) U/ml, and the positive rates were 76.66% and 43.33% in study group,respectively,and all higher than those of control groups(P <0.01 ).The level of CA72-4 was high in two of 32 patients with gastratrophia,and one was diagnosed as gastric carcinoma after nine months follow-up.Conclusion The combined detection of CA72-4 and CA19-9 provide main evidence for the diagnosis of gastric cancer and diagnostric significance of advanced gastric cancer.