Monoamine oxidase inhibitory components from the roots ofSophora flavescens |
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Authors: | Ji-Sang Hwang Seon A Lee Seong Su Hong Kyong Soon Lee Myung Koo Lee Bang Yeon Hwang Jai Seup Ro |
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Institution: | College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea. |
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Abstract: | In our search for monoamine oxidase (MAO) inhibitors from natural resources, we found that the methanol extract of the roots of Sophora flavescens showed an inhibitory effect on mouse brain monoamine oxidase (MAO). Bioactivity-guided isolation of the extract yielded two known flavonoids, formononetin (1) and kushenol F (2), as active compounds along with three inactive compounds, oxymatrine (3), trifolirhizin (4), and beta-sitosterol (5). Formononetin (1) and kushenol F (2) showed significant inhibitory effects on MAO in a dose-dependent manner with IC50 values of 13.2 and 69.9 microM, respectively. Formononetin (1) showed a slightly more potent inhibitory effect against MAO-B (IC50: 11.0 microM) than MAO-A (IC50: 21.2 microM). Kushenol F (2) also preferentially inhibited the MAO-B activity than MAO-A activity with the IC50 values of 63.1 and 103.7 microM, respectively. |
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Keywords: | Sophora flavescens Leguminosae Formononetin Kushenol F Monoamine oxidase inhibitor |
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