一氧化氮合酶2、3在非小细胞肺癌中的表达及其临床意义

目的 :研究一氧化氮合酶 2 (NOS2 )、一氧化氮合酶 3(NOS3)在非小细胞肺癌 (NSCLC)中的表达及其与肿瘤血管形成、淋巴结转移的关系。　方法 :用免疫组化 (S P法 )染色技术对 95例NSCLC石蜡组织标本的NOS2、NOS3和肿瘤内微血管密度 (IMVD)进行检测和分析。　结果 :NOS3与组织学分型、IMVD和淋巴结转移有关 (P<0 .0 5 ) ;NOS2与IMVD有关 (P <0 .0 5 )。　结论 :NOS2、NOS3的检测对于临床判断NSCLC转移和预后有一定的应用价值

Expressions of NOS2 and NOS3 in human non-small cell lung cancer and the relationship with tumor angiogenesis and lymph node metastasis

Objective: To investigate the expression and distribution of NOS2 and NOS3 in human non-small cell lung cancer (NSCLC),and to evaluate the relationship between their expression and tumor angiogenesis and lymph node metastasis. Methods: the expression of NOS2, NOS3 and IMVD in 95 patients with NSCLC were examined using immunohistochemical methods (S-P), and the relationship between them and many clinicopathological parameters was analyzed. Results: The positive expression of NOS3 was associated with histological subtype, IMVD and lymph node metastases of NSCLC(P<0.05), while NOS2 was associated with IMVD(P<0.05). Conclusion: NOS2 and NOS3 may be synergetic in tumor angiogenesis and lymph metastasis of human NSCLC.The detection of NOS2 and NOS3 may be valuable for the prediction of human NSCLC metastasis and prognosis.