Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice. |
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| Authors: | M G Stevens G W Pugh Jr and L B Tabatabai |
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| Institution: | Brucellosis Research Unit, National Animal Disease Center, Ames, Iowa 50010. |
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| Abstract: | Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone. |
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