| 低剂量吉西他滨单药治疗老年晚期非小细胞肺癌的观察 |
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| 引用本文： | 郝琳,王怀瑾,王冰,许慧,戚震伟.低剂量吉西他滨单药治疗老年晚期非小细胞肺癌的观察[J].临床肿瘤学杂志,2006,11(1):27-28,31. |
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| 作者姓名： | 郝琳 王怀瑾 王冰 许慧 戚震伟 |
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| 作者单位： | 116021,辽宁大连,大连今华夏医院肿瘤内科;116044 大连大学附属医院肿瘤中心 |
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| 摘 要： | 目的:观察低剂量吉西他滨单药治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效。方法:国产吉西他滨600mg/m2,静脉滴注30分钟,第1、8、15天,28天为1周期,治疗65岁以上NSCLC患者31例。结果:31例患者共化疗95个周期,总有效率(CR PR)29.0%(9/31),临床受益率61.3%(19/31)。毒副作用以白细胞和血小板下降为常见,但均可耐受。结论:低剂量国产吉西他滨单药治疗老年NSCLC有着较好疗效且病人耐受性较好。
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| 关 键 词： | 非小细胞肺癌 老年患者 吉西他滨 化学疗法 |
| 文章编号： | 1009-0460（2006）01-0027-03 |
| 收稿时间： | 2005-06-02 |
| 修稿时间： | 2005-08-18 |
Observation of low-dose gemcitabine in treating elderly patients with non-small cell lung cancer |
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| HAO Lin,WANG Huai-jin,WANG Bing,XU Hui,QI Zhen-wei.Observation of low-dose gemcitabine in treating elderly patients with non-small cell lung cancer[J].Chinese Clinical Oncology,2006,11(1):27-28,31. |
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| Authors: | HAO Lin WANG Huai-jin WANG Bing XU Hui QI Zhen-wei |
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| Abstract: | Objective:To investigate the clinical efficacy of elderly patients with advanced NSCLC treated with low-dose gemcitbine.Methods:31 patients aged over 65 with advanced NSCLC were treated with Zefei 600mg/m2 on days 1, 8 and 15. The schedule was repeated every 28 days.Results:The recent efficacy: 31 patients were given 95 cycles, overall response rate was 29.0%(9/31); the clinical benefitial response was 61.3%(19/31). The main toxicities were leucopenia and thrombocytopenia. Conclusion:The low-dose gemcitabine is a feasible, well-tolerated, and active scheme in the treatment of elderly patients with advanced NSCLC. |
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| Keywords: | NSCLC Elderly Patients Gemcitabine Chemotherapy |
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