| 7-氯-6-氟-4-羟基-2-巯基喹啉-3-羧酸乙酯的合成 |
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| 引用本文： | 赵杰,崔新强. 7-氯-6-氟-4-羟基-2-巯基喹啉-3-羧酸乙酯的合成[J]. 齐鲁药事, 2004, 23(2): 50-51 |
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| 作者姓名： | 赵杰 崔新强 |
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| 作者单位： | 1. 南洋教育集团,济南,250061
2. 山东省医药工业研究所,济南,250100 |
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| 摘 要： | 以价格低廉的 3-氯 - 4 -氟苯胺为起始原料,合成普卢利沙星的关键中间体 7-氯 - 6 -氟 - 4 -羟基苯并[h]吡啶- 3-甲酸乙酯获得成功。此法成本低,收率高,为进一步探索普卢利沙星的合成方法打下基础
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| 关 键 词： | 普卢利沙星 中间体 合成 |
| 文章编号： | 1672-7738(2004)02-0050-02 |
Synthesis of 7-chloro-6-fluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylic ethylester |
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| Zhao Jie , Cui Xin-qiang. Synthesis of 7-chloro-6-fluoro-4-hydroxy-2-mercaptoquinoline-3-carboxylic ethylester[J]. qilu pharmaceutical affairs, 2004, 23(2): 50-51 |
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| Authors: | Zhao Jie Cui Xin-qiang |
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| Affiliation: | Zhao Jie , Cui Xin-qiang 1 |
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| Abstract: | chloro-4-fluorophenylamine was used as the cheap material for the synthesis of 7-chloro-6-fluoro-4-hydroxy-phenyl [h] pyridine-3-ethyl formate , the intermediate of Prulifloxacin . This new method is meaningful for the synthesis of Prulifloxacin for lower cost and good yield . |
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| Keywords: | Prulifloxacin intermediate synthesis |
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