| 乌司他丁对心肺转流患者血浆血栓调节蛋白、血管性假血友病因子、内皮素-1和一氧化氮水平的影响 |
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| 引用本文： | 陈春,龚园,汤和青,侯俊,方为,冯雪刚,孙德海. 乌司他丁对心肺转流患者血浆血栓调节蛋白、血管性假血友病因子、内皮素-1和一氧化氮水平的影响[J]. 重庆医学, 2010, 39(8) |
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| 作者姓名： | 陈春 龚园 汤和青 侯俊 方为 冯雪刚 孙德海 |
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| 作者单位： | 三峡大学第一临床医学院麻醉科,湖北宜昌,443003;湖北省宜昌市中心人民医院麻醉科,443003 |
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| 摘 要： | 目的探讨乌司他丁对心肺转流(CPB)患者全身性血管内皮细胞(VEC)的急性损伤的保护作用。方法将30例心血管择期手术患者(瓣膜置换术)随机分为两组,观察组CPB过程中给予乌司他丁,对照组CPB过程中给予生理盐水,每组15例。分别于术前、转流前、转流后30 min、停转流、手术结束、术后1 d和术后3 d动态监测两组患者血浆可溶性血栓调节蛋白(sTM)、血管性假血友病因子(vWF)、内皮素-1(ET-1)和一氧化氮(NO)的变化。结果两组患者血浆sTM、vWF和ET-1在CPB期间和术后1 d均显著增高,NO在CPB期间和术后1 d均显著下降;观察组的指标术后3 d恢复到术前水平。对照组未能恢复。观察组患者CPB期间至术后3 d的血浆sTM、vWF和ET-1均低于对照组,NO指标均高于对照组。结论CPB可导致全身性VEC的急性损伤,乌司他丁可以减轻CPB导致的VEC损伤。
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| 关 键 词： | 乌司他丁 可溶性血栓调节蛋白 血管性假血友痛因子 内皮素-1 一氧化氯 心肺转流 |
Effects of ulinastatin on serum sTM,vWF,ET-1 and NO in patients undergoing cardiopulmonary bypass |
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| CHEN Chun,GONG Yuan,TANG He-qing,et al.. Effects of ulinastatin on serum sTM,vWF,ET-1 and NO in patients undergoing cardiopulmonary bypass[J]. Chongqing Medical Journal, 2010, 39(8) |
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| Authors: | CHEN Chun GONG Yuan TANG He-qing et al. |
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| Affiliation: | CHEN Chun1,GONG Yuan2,TANG He-qing1,et al.(1.Department of Anesthesia,the First College of Clinical Medical Science,Three Gorges University,Yichang,Hubei 443003,China,2.Department of Anesthesia,Center Hospital of Yichang,China) |
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| Abstract: | Objective To study the protective effect of ulinastatin on the vascular endothelial cell acute injury in the patients undergoing cardiopulmonary(CPB).Methods Thirty patients scheduled for cardiac valvular replacement under CPB were divided into two groups with 15 cases each,the patients in the test group were infused intravenously after the induction of anesthesia and during CPB,respectively.Each infusion time was about 1 h.In the control group,normal saline was given instead of UTI.Blood samples were withd... |
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| Keywords: | ulinastatin soluble thrombomodulin von Willebrand factor endothelin-1 nitric oxide cardiopulmonary bypass |
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