| bcr3／abl2反义寡核苷酸诱导慢性髓细胞白血病凋亡作用的研究 |
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| 引用本文： | 尚振川 孙秉中. bcr3／abl2反义寡核苷酸诱导慢性髓细胞白血病凋亡作用的研究[J]. 中国癌症杂志, 1998, 8(4): 264-266 |
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| 作者姓名： | 尚振川 孙秉中 |
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| 作者单位： | 海军401医院血液内科!青岛266071(尚振川，谢小平)，第四军医大学西京医院血液科(孙秉中，于文强，冯琦，郑英文，朱华锋) |
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| 基金项目： | 国家自然科学基金 (39670330) |
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| 摘 要： | 目的 探讨癌基因bcr_3/abl_2反义寡核苷酸(antisense oligodeoxynucleotide,ASO)对慢性髓细胞白血病(CML)的作用及其作用机理.方法 通过形态学观察、流式细胞仪(FCM)检测和片断DNA含量测定等技术研究ASO对15例初发CML的作用.结果 bcr_3/abl_2 ASO(ASO-ba)可诱导CML细胞凋亡.结论 ASO技术可为CML治疗提供一项新手段.
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| 关 键 词： | 白血病 髓细胞性 慢性 癌基因 凋亡 反义寡核苷酸 |
bcr_3/abl_2 ANTISENSE OLIGODEOXYNUCLEOTIDE INDUCES APOPTOSIS IN CHRONIC MYELOID LEUKEMIA |
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| Shang Zhenchuan,Sun Bingzhong,Xie Xiaoping,et al.. bcr_3/abl_2 ANTISENSE OLIGODEOXYNUCLEOTIDE INDUCES APOPTOSIS IN CHRONIC MYELOID LEUKEMIA[J]. China Oncology, 1998, 8(4): 264-266 |
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| Authors: | Shang Zhenchuan Sun Bingzhong Xie Xiaoping et al. |
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| Affiliation: | Shang Zhenchuan,Sun Bingzhong,Xie Xiaoping,et al. Navy 401 Hospital,Qingdao 266071 |
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| Abstract: | PURPOSE To investigate the effects of bcr3/abl2 anisense oligodeoxynucleotide (ASO) on chronic myeloid leukemia (CML). METHODS The effects of bcr3/abl2 ASO in 15 CML patients were evaluated by morphological observation, flow cytometer (FCM) techniques and DNA fragment measurement. RESULTS bcr3/abl2 ASO can induce apoptosis in CML. CONCLUSION Antisense techniques may provide a new way to cure CML. |
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| Keywords: | Leukemia. myeloid. chronic Oncogene Apoptosis Antisense oligodeoxynucleotide |
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