Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy |
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Authors: | Resch Ulrike Tatzber Franz Budinsky Alexandra Sinzinger Helmut |
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Institution: | Medical University of Vienna, Wilhelm Auerswald Atherosclerosis Research Group, Vienna, Austria. ulrike.resch@meduniwien.ac.at |
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Abstract: | AIMS: To examine the effect of 24 weeks' rosuvastatin treatment on oxidative stress and changes in immune response to oxidized low-density lipoprotein (LDL). METHODS: This was an open-label study of patients in Austria receiving 10 or 40 mg rosuvastatin daily alternately during 12 and 24 weeks. Circulating concentrations of antibodies to malondialdehyde-oxidized LDL (MDA-LDL), both IgG and IgM type, to copper-oxidized LDL (Cu-OxLDL-IgG), concentrations of oxidized LDL complexed to IgG (OxLDL-IC) and markers of oxidative stress and systemic inflammation in subjects with plasma LDL cholesterol concentrations between 130 mg dl-1 and 250 mg dl-1 and triglycerides
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Keywords: | autoantibodies oxidative stress oxidatively modified low-density lipoprotein rosuvastatin |
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