2型糖尿病患者血清低密度脂蛋白免疫复合物的检测及临床意义

采用ELISA法测定102例2型糖尿病（T2DM）患者（其中54例合并大血管病变）、45例大血管病变患者及30例正常对照者的血清低密度脂蛋白免疫复合物（LDL-ICs）浓度。T2DM及大血管病变患者血LDL—ICs浓度均高于正常对照者，糖尿病合并大血管病变者高于单纯糖尿病、单纯大血管病变患者；血清LDL-ICs浓度与体重指数、血糖化血红蛋白、血压、总胆固醇、甘油三酯水平呈正相关，与高密度脂蛋白胆固醇水平呈负相关，与低密度脂蛋白胆固醇水平无相关性。LDL-ICs、血压、糖化血红蛋白是糖尿病大血管病变的危险因素。

Low-density lipoprotein immune complexes in patients with type 2 diabetes

This study was designed to observe the clinical value of low-density lipoprotein immune complexes (LDL-ICs) in patients with type 2 diabetes mellitus (T2DM). Fifty-four patients with type 2 diabetes + macroangiopathy (DM-MA group), 48 patients with type 2 diabetes (DM group), 45 patients with macroangiopathy ( MA group), and 30 normal controls ( NC group) were enrolled. LDL-ICs levels in the DM-MA group were significantly higher than those in the other three groups. The levels of LDL-ICs in the MA group were higher than those in the NC and DM groups. There was a significant difference in LDL-ICs between the DM and NC groups. LDL-ICs levels were positively related with body mass index (BMI), glycesylated hemoglobin Alc(HbAlc), blood pressure, total cholesterol, and triglyceride. There was no significant relationship between low-density lipsprotcin cholesterol and LDL-ICs. A significantly negative correlation was recorded between high-density lipoprotein cholesterol and LDL-ICs. Our study suggests that LDL-ICs, blood pressure, and HbAlc may be risk factors of macroangiopathy in type 2 diabetic patients.