瘦素及其受体在胃癌中的表达及意义

目的：探讨瘦素（leptin）、瘦素受体（leptin receptor）在胃癌发生发展中的意义及其相互关系.方法：应用免疫组织化学SP法检测19例正常胃黏膜、19例慢性萎缩性胃炎伴肠化、18例不典型增生、15例早期胃癌、45例进展期胃癌组织中leptin、leptin receptor表达情况.结果：1eptin随胃癌的发展阳性率逐渐增高（15.8%,31.6%,44.4%,53.3%,80.0%;P＜0.01）;leptin表达与组织学分级、浆膜浸润、淋巴结转移和TNM分期有关（P＜0.05）.leptin receptor阳性表达率在胃癌发展过程中差异无显著性（P＞0.05）.leptin和leptin receptor在胃癌组织中的表达无相关性（rs=-0.005,P＞0.05）.结论：leptin、leptin receptor共同参与了胃癌的发生与发展.

Expressions of Leptin and Leptin Receptor in Gastric Carcinoma and Its Significance

Objective:To evaluate the roles of leptin and leptin receptor in the development of gastric carcinoma(GC) as well as their interrelation.Methods:Sreptacidin/peroxidase(SP) technique was adopted to examine the expressions of leptin and leptin receptor in 19 cases of normal gastric mucosa,19 cases of chronic atrophic gastritis with intestinal metaplasia(CAG+IM),18 cases of atypical hyperplasia(Dys),15 cases of early gastric carcinoma and 45 cases of advanced gastric carcinoma.Results:With the development of GC,the positive rate of leptin was increased gradually(15.8%,31.6%,44.4%,53.3%,80.0%;P<0.01).Leptin positive expression was correlated with the histologic stage,serosa infiltration,lymph node metastasis and the TNM stage(P<0.05).With the development of GC,the positive rate of leptin receptor was varied unobviously(P>0.05).There was no relationship between leptin expression in the GC and that of leptin receptor(r_s=-0.005,P>0.05).Conclusion:Leptin and leptin receptor contributed to the development of GC.