甲状腺分化癌组织中雌激素受体的表达

目的:探讨甲状腺分化癌(DTC)组织中雌激素受体(ER)表达的临床意义。方法:应用免疫组化SP法 对43例DTC(包括39例乳头状癌,4例滤泡状癌),30例甲状腺良性腺瘤及16例腺瘤旁正常甲状腺组织进行ER 检测。结果:DTC、甲状腺瘤及正常组织中ER的阳性率分别为53.6%(23/43)、26.7%(8/30)及12.5%(2/16), DTC中ER阳性率明显高于腺瘤及正常组织(P<0.05);DTC组织ER阳性率女性高于男性;<45岁者高于≥45岁 者;与肿瘤大小、病灶多少、肿瘤分期及淋巴结转移无关。结论:DTC可能为雌激素依赖性肿瘤。

Expression of estrogen receptor in differentiated thyroid carcinoma

Aim: To investigate the clinical significance of estrogen receptor(ER) expression in differentiated thyroid carcinoma(DTC) tissue.Methods: A total of 43 cases of DTC(including 39 cases of papillary thyroid carinoma and 4 cases of follicular thyroid carcinoma),30 cases of thyroid adenoma, and 16 cases of normal thyroid tissue around thyroid adenoma were subjected to detect ER by using immunohistochemical SP method. Results: The positive rates of ER in the DTC,the thyroid adenoma,and normal thyroid tissue were 53.6%(23/43), 26.7%(8/30), and 12.5%(2/16),respectively.The positive rate in DTC was significantly higher than those in the thyroid adenoma and the normal thyroid tissue(P<0.05). The positive rates in female with DTC was significantly higher than that in male, and that in those aged less than 45 years was significantly higher than that in those aged more than 45 years. Conclusion: DTC may be a kind of estrogen-dependent tumor.