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| 天花粉及其组份对小鼠NK细胞杀伤活性的影响 | |
| 引用本文： | 田维毅,马春玲,白惠卿.天花粉及其组份对小鼠NK细胞杀伤活性的影响[J].贵州医药,2001,25(11):982-984. |
| 作者姓名： | 田维毅 马春玲 白惠卿 |
| 作者单位： | 1. 贵阳中医学院微生物免疫学教研室, 2. 山东临沂医学专科学校 3. 北京医科大学免疫系 |
| 摘 要： | 目的：探讨天花粉及其组份对小鼠NK细胞杀伤活性的影响。方法：使用LDH（乳酸脱氢酶）释放法，测定天花粉煎剂、天花粉多糖、天花粉蛋白（ TCS）注射液对小鼠NK细胞杀伤活性的影响，进而探讨天花粉及其组份抗肿瘤活性及机制。结果：天花粉煎剂（4g/kg）、天花粉多糖（200mg/kg）、TCS注射液（6mg/kg）能明显提高小鼠NK细胞的杀伤活性（P＜0．05），且具有剂量差异性。结论：提示天花粉及其组份具有体内抗肿瘤活性，其机制与促进小鼠NK细胞杀伤活性有关。 |
| 关 键 词： | 天花粉 组份 NK细胞活性 中药 植物药 |
Effects of Radix Trichosanthis and its contents on NK Cells' killing activity of mice |
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| Tian Weiyi,Ma Chun Ling,Bai Hui Qing.Effects of Radix Trichosanthis and its contents on NK Cells' killing activity of mice[J].Guizhou Medical Journal,2001,25(11):982-984. | |
| Authors: | Tian Weiyi Ma Chun Ling Bai Hui Qing |
| Institution: | Tian Weiyi,Ma Chun Ling,Bai Hui Qing Department of Immunology,Guiyang College of TCM,Guiyang 550002 |
| Abstract: | Objective To study the effect of radix Trichosanthis on NK cells killing activity of mice.Methods Effects of Radix Trichosanthis Decoction(RTD), Radix Trichosanthis Poly-saccharides(RTP) and Trichosanthin Injection(TCSI) on NK cells'killing activity of mice were measured by Lactate dehydrogenase(LDH) release assay. It's antitumer activity and mechanism of Radix Trichosanthis(RT) and contents were studied.Results RTD(4g/kg), RTP(200mg/kg) and TCSI(16mg/kg) can improve NK cells' killing activity of mice obviously, and there were correlation between its dose and efficency.Conclusion It indicates that RT and its contents have the antitumer activity in vivo and its mechanism correlates with improving NK cells' killing activity. |
| Keywords: | Radix Trichosanthis Contents NK cells'killing activity |
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