AIDS伴发的淋巴瘤的研究进展

与普通人群相比人类获得性免疫缺陷病毒(HIV)感染患者患霍奇金淋巴瘤和非霍奇金淋巴瘤的机率都大有提高。高效抗逆转录病毒治疗的免疫重建功能使得获得性免疫缺陷综合征(AIDS)患者发生机会性感染的机率大为下降，恶性肿瘤越来越成为AIDS晚期患者死亡的重要原因。目前认为非霍奇金淋巴瘤是AIDS患者中居第2位的恶性肿瘤，仅排在Kaposi肉瘤之后。近几年来的分子生物学研究使人们对这种肿瘤有了新的分类，且对它发病机制、临床表现、流行病学都有了新的认识，治疗方法和预后得到极大的改善。

Advances in acquired immuno-deficiencysyndrome-related lymphoma

Human immuno-deficiency virus-infected patients are at an increased risk for developing both Hodgkin and non-Hodgkin lymphoma when compared with the general population.With the remarkable decrease in the incidence of opportunistic infections since the availability of highly active antiretroviral therapy(HAART),malignancy in this population is a leading cause of morbidity and mortality.Acquired immuno-deficiency syndrome-related non-Hodgkin lymphoma(ARL) is now the second most common cancer associated with human immuno-deficiency virus after Kaposi sarcoma.New categories of ARL have appeared with the recent advances in biology and new knowledge of the pathogenesis,epidemiology,clinical symptom of ARL in the era of HAART have been got.The management of patients is developed and the prognosis is improved greatly.