阿托伐他汀钙对动脉粥样硬化大鼠血脂水平及CRP-mRNA表达的影响

目的探讨阿托伐他汀钙对动脉粥样硬化（AS）大鼠血脂水平及CRP—mRNA表达的影响。方法选取45只健康雄性大鼠随机分为3组，对照组喂食基础饲料，AS模型组、观察组均喂食高脂饲料，4周后观察组给予阿托伐他汀钙灌胃，8周后测量所有大鼠的低密度、高密度脂蛋白胆固醇（LDL—C、HDL—C）和CRP—mRNA表达水平。结果观察组的LDL—C明显低于对照组和AS模型组，HDL—C明显高于对照组和AS模型组，差异有统计学意义（P〈0．05）。AS模型组的LDL—C明显高于对照组，HDL—C明显低于对照组，差异有统计学意义（P〈0．05）。观察组的CRP—mRNA表达水平明显低于AS模型组，差异有统计学意义（P〈0．05）。结论阿托伐他汀钙能明显降低AS大鼠的LDL～C，升高HDL—C，抑制AS段CRP—mRNA表达，从而延缓AS的进程。

Influence of atorvastatin calcium on lipid level and CRP-mRNA expression of rat with atherosclerosis

Objective To explore influence of atorvastatin calcium on lipid level and CRP-mRNA expression of rat with atherosclerosis （AS）.Methods 45 healthy male rats were selected and randomly assigned to three groups.Control group was given basic food,AS model group and observation group were given food with high fat.Four weeks later,ob- servation group was forced to be given atorvastatin calcium.Eight weeks later,the level of LDL-C,HDL-C and CRP- mRNA expression were measured.Results LDL-C level of observation group was signifieandy lower than that of control group and AS model group,HDL-C level of observation group was significantly higher than that of control group and AS model group,with statistical difference（P〈O.O5）.LDL-C level of AS model group was significantly higher than that of control group,HDL-C level of AS model group was significantly lower than that of control group,with statistical differ- enee（P〈O.05）.CRP-mRNA expression level of AS model group was significantly higher than that of control group,with statistical difference （P〈0.05）.Conclusion Atorvastatin calcium can significantly lower LDL-C level of the rat with AS, increase HDL-C level and inhibit CRP-mRNA expression of AS,which help delay progress of AS.