复方甘草酸单铵S治疗HBV标志物阳性合并结核病的效果观察

目的 观察复方甘草酸单铵S治疗HBV标志物（M）阳性合并结核病的临床效果.方法 选择90例HBVM阳性合并结核病患者,随机分为3组,安慰组30例单纯给予抗结核药物;对照组28例给予门冬氨酸钾镁、维生素C、肌苷等常规治疗;治疗组32例给予复方甘草酸单铵S 160mg加入5％葡萄糖250 ml静滴,每日1次,疗程为4周.比较治疗前后肝功能变化.结果 治疗后治疗组、对照组、安慰组的显效率和总有效率分别是87.5％和96.9％、53.5％和85.6％、20.0％和53.3％,治疗组和对照组显效率差异有统计学意义（P＜0.05）,治疗组和安慰组显效率和总有效率差异均有统计学意义（P＜0.05）.结论 复方甘草酸单铵S能降低HBV M阳性合并结核病治疗过程中肝损害的发生率,疗效优于门冬氨酸钾镁.

Clinical effectiveness of compound ammonium glycyrrhetate S on tuberculosis with HBV marker-positive

Objective To observe the effects of compound ammonium glycyrrhetate S for tuberculosis with HBV mark- er-positive. Methods 90 patients were randomly divided into 3 groups. The placebo group（n=30） was given antituber- culosis drugs;the control group（n=28） was given potassium magnesium aspartate for injection, vitamin C,inosine conven- tional therapy. The treatment group （n=32） was given compound ammonium glyeyrrhetate S for injection,160 mg daily. After 4 weeks, the changes of hepatic function was compared. Results After treatment, the markedly effective rate and total effective rate in treatment group, control group, placebo group were 87.5% and 96.9%,53.5% and 85.6% ,20.0% and 53.3% ,the markedly effective rate of treatment group, control group was significantly different （P〈0.05）, the markedly effective rate and total effective rate between treatment group and placebo group was significantly different （P〈0.05）.Conclusion Compound ammonium glyeyrrhetate S can reduce the incidence rates of hepatic injuries on tu- berculosis with hepatitis B,the clinical effectiveness is better than potassium magnesium aspartate.